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US 2020/0109377 A1Published application
Increasing Cellular Lipid Production by Increasing the Activity of Diacylglycerol Acyltransferase and Decreasing the Activity of Triacylglycerol Lipase
AssigneeNovogy, Inc.
InventorsVasiliki Tsakraklides, Elena E. Brevnova
Life of this patent
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Abstract
Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up-regulating diacylglycerol acyltransferase and down-regulating triacylglycerol lipase. In some embodiments, a DGA1 protein is expressed and a native TGL3 gene is knocked out, thereby increasing the synthesis of triacylglycerol and decreasing its consumption, respectively.
Claims8
-13. (canceled)
A method of increasing the lipid content of a cell, comprising transforming a parent cell with a first nucleic acid and a second nucleic acid;
- wherein said first nucleic acid increases the activity of a native diacylglycerol acyltransferase or comprises a diacylglycerol acyltransferase gene;
- and said second nucleic acid decreases the activity of a triacylglycerol lipase.
Dependencies are inferred from the claim text.