Process, computer-accessible medium and system for generating a biological model associated with disease
AssigneeNew York University
InventorsLoes Olde LOOHUIS, BHUBANESWAR MISHRA, ANDREAS WITZEL
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AssigneeNew York University
InventorsLoes Olde LOOHUIS, BHUBANESWAR MISHRA, ANDREAS WITZEL
Estimating the term…
The present disclosure relates to exemplary embodiments of method, computer-accessible medium, system and software arrangements for, e.g., Cancer Hallmark Automata, a formalism to model the progression of cancers through discrete phenotypes (so-called hallmarks). The precise computational model described herein includes the automatic verification of progression models (e.g., consistency, causal connections, etc.), classification of unreachable or unstable states (e.g., “anti-hallmarks”) and computer-generated (individualized or universal) therapy plans. Exemplary embodiments abstractly model transition timings between hallmarks as well as the effects of drugs and clinical tests, and thus allows formalization of temporal statements about the progression as well as notions of timed therapies. Certain exemplary models discussed herein can be based on hybrid automata (e.g., with multiple clocks), for which relevant verification and planning algorithms exist.
A non-transitory computer-accessible medium having stored thereon computer executable instructions for directing an application of at least one therapy for use in treating a cancer in at least one patient, wherein, when the executable instruction are executed by a computing hardware arrangement, configure the computing hardware arrangement to perform procedures comprising:
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A method for treating a cancer in at least one patient, comprising:
A system for directing an application of at least one therapy for use in treating a cancer in at least one patient, comprising:
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The computer-accessible medium according to 18, wherein the states are based on data derived from at least one of clinical data or simulation data.
The computer-accessible medium according to 18, wherein the data is received from (i) an electronic health record, or (ii) a source associated with at least one of omics, genomics or transcriptomics.
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Dependencies are inferred from the claim text.