Biosensor for multi-analyte characterization
AssigneeInternational Business Machines Corporation
InventorsHARIKLIA DELIGIANNI, BRUCE B. DORIS, STEVEN J. HOLMES, QINGHUANG LIN, ROY R. YU
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Abstract
Embodiments of the present invention are directed to a semiconductor device. A non-limiting example of the semiconductor device includes a semiconductor substrate. The semiconductor device also includes a plurality of metal nanopillars formed on the substrate. The semiconductor device also includes an amperometric sensor associated with one of the plurality of nanopillars, wherein the amperometric sensor is selective to an enzyme-active neurotransmitter. The semiconductor device also includes a resistivity sensor associated with a pair of nanopillars, wherein the resistivity sensor is selective to an analyte.
Claims20
A computer-implemented method of multi-analyte detection, the method comprising:
- receiving, by a processor, a signal from a multi-analyte sensor in contact with a biological tissue, wherein the multi-analyte sensor comprises a resistivity sensor and an amperometric sensor;
- determining, by the processor, a resistivity value from the resistivity sensor;
- generating, by the processor, a concentration of a first analyte based at least in part upon the resistivity value;
- determining, by the processor, an electrical current from the amperometric sensor;
- and
- generating, by the processor, a concentration of a second analyte based at least in part upon the electrical current.
A computer-implemented method of multi-analyte detection, the method comprising:
- providing a multi-analyte sensor comprising a sensing layer formed on an interface layer, the sensing layer comprising an array of alternating chemical sensors, the array of alternating chemical sensors comprising a first sensor type and a second sensor type, wherein the first sensor type comprises a resistivity sensor and the second sensor type comprises an amperometric sensor;
- providing a processor communicatively coupled to the multi-analyte sensor;
- receiving, by the processor, a resistivity value from the resistivity sensor;
- generating, by the processor, a concentration of a first analyte based at least in part upon the resistivity value;
- receiving, by the processor, an electrical current from the amperometric sensor;
- and
- generating, by the processor, a concentration of a second analyte based at least in part upon the electrical current.
Dependencies are inferred from the claim text.