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US 2020/0087696 A1Published application
Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
AssigneeGlykos Finland Oy
InventorsChristopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
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Abstract
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
Claims11
1-16. (canceled)
A Myceliophthora thermophila filamentous fungal cell comprising at least one endogenous amp or pep protease having no protease activity and a recombinant polynucleotide encoding a mammalian polypeptide, wherein a gene encoding an endogenous amp protease having at least 98% identity to SEQ ID NO:
- 767, 774 or 780 or pep protease having at least 98% identity to XP_003667167.1 of the Myceliophthora thermophila filamentous fungal cell comprises a mutation that eliminates the activity of the endogenous amp or pep protease.
Dependencies are inferred from the claim text.