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US 2020/0087287 A1Published application
Crystalline pharmaceutical and methods of preparation and use thereof
AssigneeSarcode Bioscience Inc.
InventorJohn BURNIER
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Abstract
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention.
Claims15
A method of synthesizing a compound of Formula I:
- comprising the steps:
- a) base hydrolysis of Formula AA with a base in an aprotic solvent:
- wherein R is a carbon containing moiety;
- and
- b) isolating a compound of Formula I.
2 more elements
A method of synthesizing a compound of Formula I:
- comprising the steps:
- a) acid hydrolysis of Formula AA with an acid in an aprotic solvent:
- wherein R is a carbon containing moiety;
- and
- b) isolating a compound of Formula I.
2 more elements
Dependencies are inferred from the claim text.