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OwnerGlen Eugene Mikesell, Han Chang +4inventors
InventorsGlen Eugene Mikesell, Han Chang, Joshua N. Finger, Guchen Yang, Robert James Peach, Henry Shen
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The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
1-52. (canceled)
An isolated nucleic acid molecule encoding a polypeptide comprising an amino acid sequence of SEQ ID NO:
An isolated nucleic acid molecule encoding a polypeptide comprising at least 20 contiguous amino acids of SEQ ID NO:
An isolated nucleic acid molecule that encodes a polypeptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:
An isolated nucleic acid molecule comprising a nucleotide sequence comprising at least 60 contiguous nucleotides of SEQ ID NO:
An isolated nucleic acid molecule comprising a nucleotide sequence comprising at least 25 contiguous nucleotides of SEQ ID NO:
An isolated nucleic acid molecule comprising:
Dependencies are inferred from the claim text.