Systems and methods for preparation of platelets
AssigneeCerus Corporation
InventorsElan WEINER, William GREENMAN
Life of this patent
Estimating the term…
Abstract
Provided are methods, systems and compositions for the preparation of platelets, including improved methods and systems for preparing apheresis derived platelet units suitable for infusion and compositions comprising such platelet units.
Claims149
A method of preparing a plurality of platelet units suitable for infusion, comprising:
- a) collecting a first platelet donation by apheresis from a first donor,
- b) collecting a second platelet donation by apheresis from a second donor,
- c) combining the first platelet donation and the second platelet donation to yield a pooled platelet preparation, and
- d) separating the pooled platelet preparation into a plurality of platelet units each in an individual container, wherein the plurality of platelet units comprises a greater number of platelet units than the total number of platelet units that can be prepared from the first platelet donation and second platelet donation without combining the first and second platelet donations.
A method of preparing a plurality of platelet units suitable for infusion, comprising:
- a) maintaining an inventory log of an inventory of apheresis-collected platelet preparations, the inventory log comprising for each platelet preparation a unique identifier, a donor blood type, a donation time and a quantity of platelets in the preparation,
- b) identifying an available donor suitable for donating platelets by apheresis,
- c) selecting from the inventory log at least one platelet preparation in the inventory for combining with platelets collected from the available donor,
- d) collecting a new platelet donation by apheresis from the available donor,
- e) combining the at least one selected platelet preparation and the new platelet donation to yield a pooled platelet preparation, and
- f) separating the pooled platelet preparation into a plurality of platelet units each in an individual container, wherein the plurality of platelet units comprises a greater number of platelet units than the total number of platelet units that can be prepared from the at least one selected platelet preparation and the new platelet donation without combining the at least one selected platelet preparation and new platelet donation.
A method of preparing two or more therapeutic dosage units of platelets comprising:
- a) combining two or more apheresis-derived platelet donor units to form a pooled platelet composition,
- b) subjecting the pooled platelet composition to a pathogen inactivation process, and
- c) separating the pooled platelet composition into two or more therapeutic dosage units of platelets, each in an individual container.
A method for collecting a platelet donation by apheresis from a donor, comprising:
- a) maintaining an inventory log of an inventory of apheresis-collected platelet preparations, the inventory log comprising for each platelet preparation a unique identifier, a donor blood type, a donation date and a quantity of platelets in the preparation,
- b) identifying a donor suitable for donating platelets by apheresis,
- c) selecting from the inventory log one or more platelet preparations suitable for combining with a new platelet donation to be collected by apheresis from the donor,
- d) determining a target volume of the new platelet donation, wherein the target volume optimizes the number of platelet units that can be prepared from a combination comprising the new platelet donation and the one or more selected platelet preparations;
- and
- e) collecting the target volume of the new platelet donation by apheresis from the donor.
A therapeutic dosage unit of platelets suitable for infusion into a subject, wherein the therapeutic dosage unit comprises pooled apheresis-derived platelets from two or more donors, and wherein the pooled apheresis-derived platelets have been treated with a pathogen inactivating compound.
A computer-implemented method for optimization of platelet units for infusion, comprising:
- at a computer system including one or more processors and memory,
- receiving one or more values associated with one or more properties of a platelet donation;
- instructing to search, based on the received one or more values, a plurality of values associated with representations of a plurality of platelet preparations;
- determining, based on the search results, a volume of the platelet donation;
- and
- providing the determined volume of the platelet donation, wherein the determined volume of the platelet donation enables optimization of platelet units.
A non-transitory computer readable medium having instructions stored thereon for optimization of platelet units for infusion, the instructions, when executed by one or more processors of a computer system, cause the computer system to:
- receive one or more values associated with one or more properties of a platelet donation;
- instruct to search, based on the received one or more values, a plurality of values associated with representations of a plurality of platelet preparations;
- determine, based on the search results, a volume of the platelet donation;
- and
- provide the determined volume of the platelet donation, wherein the determined volume of the platelet donation enables optimization of platelet units.
A system for optimization of platelet units for infusion, comprising:
- one or more processors;
- and
- memory having instructions stored thereon, the instruction, when executed by the one or more processors, cause the computer system to:
- receive one or more values associated with one or more properties of a platelet donation;
- instruct to search, based on the received one or more values, a plurality of values associated with representations of a plurality of platelet preparations;
- determine, based on the search results, a volume of the platelet donation;
- and
- provide the determined volume of the platelet donation, wherein the determined volume of the platelet donation enables optimization of platelet units.
A computer-implemented method for optimization of platelet units for infusion, comprising:
- at a computer system including one or more processors and memory,
- receiving one or more values associated with one or more properties of a first platelet preparation;
- instructing to search, based on the received one or more values, a plurality of values associated with representations of a plurality of platelet preparations;
- selecting, based on the search results, a second platelet preparation from the representations of a plurality of platelet preparations;
- and
- providing the selected second platelet preparation, wherein the selected second platelet preparation enables optimization of platelet units.
A non-transitory computer readable medium having instructions stored thereon for optimization of platelet units for infusion, the instructions, when executed by one or more processors of a computer system, cause the computer system to:
- receive one or more values associated with one or more properties of a first platelet preparation;
- instruct to search, based on the received one or more values, a plurality of values associated with representations of a plurality of platelet preparations;
- select, based on the search results, a second platelet preparation from the representations of a plurality of platelet preparations;
- and
- provide the selected second platelet preparation, wherein the selected second platelet preparation enables optimization of platelet units.
A system for optimization of platelet units for infusion, comprising:
- one or more processors;
- and
- memory having instructions stored thereon, the instruction, when executed by the one or more processors, cause the computer system to:
- receive one or more values associated with one or more properties of a first platelet preparation;
- instruct to search, based on the received one or more values, a plurality of values associated with representations of a plurality of platelet preparations;
- select, based on the search results, a second platelet preparation from the representations of a plurality of platelet preparations;
- and
- provide the selected second platelet preparation, wherein the selected second platelet preparation enables optimization of platelet units.
A processing set for preparing a plurality of platelet units from two or more platelet donations, wherein each of the platelet units is pathogen-inactivated and suitable for infusion into a subject, the processing set comprising:
- a) a first container that contains a pathogen inactivation compound (PIC) and is suitable for combining the two or more platelet donations with the PIC;
- b) a second container, coupled to the first container, within which the two or more platelet donations in admixture with the PIC can be photochemically inactivated under sterile conditions, wherein the volume of the two or more platelet donations is sufficient to yield the plurality of platelet units;
- c) a compound absorption device (CAD) coupled to the second container such that the two or more photochemically inactivated platelet donations can be transferred from the second container to the compound absorption device under sterile conditions;
- and
- d) three or more third containers, each of which is coupled to the compound absorption device such that the two or more photochemically inactivated platelet donations can be transferred from the compound absorption device to the three or more third containers under sterile conditions to provide the plurality of platelet units,
- wherein the plurality of platelet units comprises a greater number of platelet units than the total number of platelet units that can be prepared from the two or more donations without combining the two or more platelet donations.
A kit comprising (a) a processing set, and (b) instructions for using the processing set to prepare a plurality of platelet units from two or more platelet donations, wherein each of the platelet units is pathogen-inactivated and suitable for infusion into a subject, wherein the plurality of platelet units comprises a greater number of platelet units than can be prepared from the two or more platelet donations without combining the two or more platelet donations, and
- wherein the processing set comprises:
- 1) a first container that contains a pathogen inactivation compound (PIC) and is suitable for combining the two or more platelet donations with the PIC;
- 2) a second container, coupled to the first container, within which the two or more platelet donations in admixture with the PIC can be photochemically inactivated under sterile conditions, wherein the volume of the two or more platelet donations is sufficient to yield the plurality of platelet units;
- 3) a compound absorption device (CAD) coupled to the second container such that the two or more photochemically inactivated platelet donations can be transferred from the second container to the compound absorption device under sterile conditions;
- and
- 4) three or more third containers, each of which is coupled to the compound absorption device such that the two or more photochemically inactivated platelet donations can be transferred from the compound absorption device to the three or more third containers under sterile conditions to provide the plurality of platelet units.
Dependencies are inferred from the claim text.