Norovirus s particle based vaccines and methods of making and using same
AssigneeChildren's Hospital Medical Center
InventorsMing Tan, Xi Jason Jiang
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Abstract
Disclosed herein are vaccine compositions, in particular, polyvalent icosahedral compositions for antigen presentation. The disclosed compositions may contain an S particle made up of recombinant fusion proteins. The recombinant fusion proteins may include a norovirus (NoV) S domain protein, a linker protein domain operatively connected to the norovirus S domain protein, and an antigen protein domain operatively connected to said linker.
Claims23
A polyvalent icosahedral composition for antigen presentation comprising an S particle, wherein said S particle comprises a recombinant fusion protein comprising
- a) a norovirus (NoV) S domain protein;
- b) a linker protein domain operatively connected to said norovirus S domain protein;
- and
- c) an antigen protein domain operatively connected to said linker.
(canceled)
A recombinant fusion protein comprising
- a) a norovirus (NoV) S domain protein;
- b) a linker protein domain operatively connected to said norovirus S domain protein;
- and
- c) an antigen protein domain operatively connected to said linker.
Dependencies are inferred from the claim text.