Algal based edible vaccines
AssigneeTransalgae Israel Ltd.
InventorOfra CHEN
Life of this patent
Estimating the term…
Abstract
The present invention provides edible vaccines comprising transgenic microalgae expressing at least one exogenous antigen or an intervening organism comprising the transgenic microalgae. The antigen expressing microalgae are used for oral delivery of the antigen to a target organism in its intact and functional form. The exogenous antigen, expressed in the microalgae, is characterized by exerting at least one immunogenic response in the subject consuming the vaccine.
Claims20
An edible vaccine comprising a transgenic eukaryotic microalga, the transgenic microalga comprising an expression cassette comprising at least one polynucleotide encoding an exogenous antigen, wherein the encoded exogenous antigen is localized within a subcellular compartment of the microalga cell, wherein the subcellular compartment is selected from the group consisting of endoplasmic reticulum, Golgi system, lysosome, and peroxisome.
An edible vaccine comprising a transgenic eukaryotic microalga, the transgenic microalga comprising an expression cassette comprising at least one polynucleotide encoding an exogenous antigen further comprising a polynucleotide encoding a vacuolar targeting peptide having an amino acid sequence at least 90% homologous to the amino acid sequence set forth in any one of SEQ ID NO:1 and SEQ ID NO:9, wherein the encoded exogenous antigen is localized within the vacuole of the microalga cell, and wherein said encoded exogenous antigen induces an immune response in a target subject consuming said vaccine against a disease caused by a pathogen.
Dependencies are inferred from the claim text.