Epimerization-free n to c solid-phase peptide synthesis

A method of synthesizing a peptide, wherein the method comprises preparing a first amino acid for synthesis, coupling an amino group of a second amino acid to the carboxyl group of the first amino acid to obtain a peptide, and optionally elongating the peptide by coupling one or more amino acids sequentially to a C-terminus of the peptide, wherein the amino acids used in the method are derivatized amino acids, and wherein the method proceeds without detectable epimerization of an amino acid at the carboxyl terminus of the peptide.