Single Wall Nanotube Constructs and Uses Thereof

A method of delivering an anticancer drug in situ to a cancer in a subject, comprising:

• administering a first component of a soluble single wall carbon nanotube (SWNT) construct having the structure SWNT-(peptide)x-(DNA1)x-(DNA2)x, said peptide targeting cells comprising the cancer;
• administering a second construct component having the structure cDNA1-E1)m and a third construct component having the structure (cDNA2-E2)n;
• self-assembling said soluble SWNT construct in situ via hybridization of the second and third construct components to the first construct component, said selfassembled SWNT construct having the structure SWNT-(peptide)x-(DNA1,2-(cDNA1-E1)m-(cDNA2-E2)n)x, wherein
• x is 1 to 300;
• m and n are independently 1 to 300;
• cDNA1 and cDNA2 are non-identical oligonucleotides;
• DNA1 and DNA2 are oligonucleotides with sequences complementary to cDNA1 and cDNA2;
• and
• E1 and E2 are enzymes;
• administering an anticancer preprodrug to the subject;
• and
• activating the drug via sequential action of the enzymes on the preprodrug thereby delivering said anticancer drug in situ to the cancer in the subject.