Treating Animal Cancers Through Programmed Cancer Cell Death
OwnerRichard Postrelinventor
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Abstract
The present invention provides systems and methods wherethrough a cancer cell's metabolic activities attract a vector to the cell to provide the cell with tools and instructions for self-destruction. A vector is engineered for attraction to and reaction with cells of higher temperature, a characteristic result of hypermetabolism inherent in the uncontrolled or extreme growth of cancerous and precancerous cells. A second engineered feature relates to the increased acidity resulting from a cancer cell's reduced reliance of mitochondrial ATP production. The engineered vector then stimulates the body's natural intracellular and extracellular innate immune responses to effect death and destruction of the targeted hypermetabolizing cells.
Claims69
An engineered vector carrying a message for inducing death in a hyperproliferative cell of a homeothermic animal, said vector comprising i) a recognition component directing said vector to a cell whose temperature is greater than the temperature of surrounding tissue;
- ii) a recognition component directing said vector to a cell whose [H+] is greater than the [H+] of surrounding tissue;
- iii) a ligand for binding said hyperproliferative cell;
- and iv) a chemical messenger that facilitates apoptosis in said hyperproliferative cell wherein said hyperproliferative cell is selected from the group consisting of:
- a cancer cell and a precancerous cell.
The engineered vector of 25 wherein said mammalian TLR comprises a feline or canine TLR.
A method for inducing death in a hyperproliferative cell in a homeothermic animal, said method comprising selecting or engineering an influenza virus to increase binding compared with a common influenza virus at an increased temperature and selecting or engineering said influenza virus to increase binding compared with a common influenza virus at an increased H+ concentration, delivering said engineered influenza virus to said homeothermic animal, and stimulating an auto-immune response in said at least one hyperproliferative cell leading to its death.
Dependencies are inferred from the claim text.