Monitoring Ion Mobility Spectrometry Environment for Improved Collision Cross Section Accuracy and Precision
AssigneeMicromass UK Limited
InventorsSteven Derek PRINGLE, Farnoush SALARZAEI, Nicholas TOMCZYK, Jason Lee WILDGOOSE
Life of this patent
Estimating the term…
Abstract
A mass spectrometer is disclosed comprising an ion mobility separator 4 for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator 4, and to control the operating environment within the ion mobility separator 4 based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.
Claims27
A mass spectrometer comprising:
- an ion mobility separator for separating ions according to their ion mobility;
- one or more first devices or stages comprising an ion source arranged upstream of said ion mobility separator;
- a monitoring device configured to monitor directly or indirectly an operating environment within said ion mobility separator by monitoring one or more pressures;
- and
- a controller configured to control said ion mobility separator based at least in part on the one or more pressures of said monitoring;
- wherein the pressure within said ion mobility separator is less than the pressure within or at said one or more first devices or stages.
2-4. (canceled)
12-18. (canceled)
20-25. (canceled)
(canceled)
29-38. (canceled)
A method of mass spectrometry comprising:
- providing an ion mobility separator for separating ions according to their ion mobility;
- providing one or more first devices or stages comprising an ion source upstream of said ion mobility separator;
- monitoring directly or indirectly an operating environment within said ion mobility separator by monitoring one or more pressures;
- and
- controlling said ion mobility separator based at least in part on the one or more pressures of said monitoring;
- wherein the pressure within said ion mobility separator is less than the pressure within or at said one or more first devices or stages.
(canceled)
(canceled)
A mass spectrometer comprising:
- an ion mobility separator for separating ions according to their ion mobility;
- one or more first devices or stages comprising an ion source arranged upstream of said ion mobility separator;
- one or more second devices or stages arranged downstream of said ion mobility separator, wherein said one or more second devices or stages comprises a mass analyser;
- a monitoring device configured to monitor directly or indirectly an operating environment within said ion mobility separator by monitoring one or more pressures;
- and
- a controller configured to control said ion mobility separator based at least in part on the one or more pressures of said monitoring;
- wherein the pressure within said ion mobility separator is greater than the pressure within or at said one or more second devices or stages.
Dependencies are inferred from the claim text.