Markers for renal disease
AssigneeIDEXX Laboratories, Inc.
InventorsMahalakshmi YERRAMILLI, Michael Randolph Atkinson, Murthy V.S.N. Yerramilli
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Abstract
This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
Claims7
A method for diagnosis and treatment of kidney disease prior to stage 3 of kidney disease comprising detecting the amount of at least one canine Cystatin A polypeptide selected from the group consisting of full length canine Cystatin A, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, in a canine patient sample from a canine patient suspected of suffering from renal disease, wherein the determining the amount of the at least one canine Cystatin A polypeptide is performed by contacting the canine patient sample with one or more antibodies or antigen binding fragments specific for canine Cystatin A under conditions suitable for polypeptide/antibody complexes to form and detecting the polypeptide/antibody complexes to determine the amount of the at least one canine Cystatin A polypeptide in the canine patient sample;
- diagnosing the canine patient with kidney disease prior to stage 3 of kidney disease wherein the amount of at least one Cystatin A polypeptide is differentially expressed as compared to a control;
- and
- treating the canine patient with (i) dialysis;
- (ii) a diet low in phosphorous and protein;
- or (iii) dialysis and a diet low in phosphorous and protein.
Dependencies are inferred from the claim text.