Erythropoietic role of resident macrophages in hematopoietic organs
AssigneeAlbert Einstein College of Medicine
InventorsAndrew Chow, Paul S. Frenette, Miriam Merad
Life of this patent
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Abstract
Methods of determining the erythroid prognosis of an anemia, methods of treating a blood disorder in a subject comprising an anemia, and methods of treating a blood disorder in a subject comprising an expanded erythron are all provided.
Claims24
A method of treating a subject having a blood disorder comprising erythropoietic stress, the method comprising administering to the subject an amount of an erythropoiesis-stimulating agent effective to treat the blood disorder.
5-10. (canceled)
A method of determining the prognosis of an erythroid compartment in a subject having a condition comprising erythropoietic stress, comprising
- obtaining a bone marrow sample and/or splenic sample from the subject and quantifying CD169+ macrophages in the sample(s),
- comparing the amount of CD169+ macrophages quantified to a predefined reference amount, and
- determining the prognosis of the erythroid compartment as a negative or a positive prognosis,
- wherein an amount of CD169+ macrophages quantified in excess of the reference amount indicates a positive prognosis, and an amount of CD169+ macrophages quantified below the reference amount indicates a negative prognosis.
(canceled)
18-23. (canceled)
A composition comprising an erythropoiesis-stimulating agent for treating a subject having a blood disorder comprising erythropoietic stress.
28-33. (canceled)
Dependencies are inferred from the claim text.