Device and method for detecting a bacterial infection
OwnerFariba NAYERIinventor
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to a device and an in vitro method for quantitatively determining the presence or absence of one or more acute phase proteins in a biological sample from an individual. Said method comprises contacting a biological sample from the individual with a device to determine relative levels of acute phase proteins produced during bacterial infection and correlating the determined levels to infection. The device used is based on inverted methachromacy and the detection level of said method and device depends on the ratio of proteoaminoglycan to Toluidine blue in the solution. The device and method can detect a bacterial infection or monitor an antibiotic therapy.
Claims21
A device for quantitatively determining the presence or absence of one or more acute phase protein(s), such as Hepatocyte Growth Factor (HGF), in a biological sample from an individual, a presence of one or more acute phase protein(s) in said biological sample being indicative of an acute bacterial infection in said individual, said device comprising
- a) at least one surface on which a composition comprising a proteoaminoglycan and toluidine blue has been immobilized,
- b) optionally a solid support onto which said at least one surface is attached,
- wherein said at least one surface comprises a material suitable for immobilization of said composition comprising proteoaminoglycan and toluidine blue.
Dependencies are inferred from the claim text.