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AssigneeNational University Corporation Hokkaido University
InventorsMasaaki Murakami, Daisuke Kamimura, Yasunobu Arima
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[Problem] The objectives of the present invention are to provide a method for making an animal that has been stressed, in particular, chronically stressed, affect or develop a specific disease or symptom, and, through elucidating the process from loading stress to affection or onset of the disease or symptom, to provide a useful tool for research and development of preventing or treating methods of the disease or symptom. [Solution] The present invention relates to a method for producing a disease modeling non-human animal having cerebrovascular inflammation, the disease modeling non-human animal, a method for screening a drug using the disease modeling non-human animal, a method for determining the risk of a disease using the presence of cerebrovascular inflammation as an indicator, and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like. The present invention enables developing pharmaceuticals for the above described diseases or the like and performing researches for elucidating their pathogenic mechanisms. The present invention also enables determining the risk of affection or onset of progressive multiple sclerosis or the like and preventing and/or treating progressive multiple sclerosis or the like.
A method for producing a disease modeling non-human animal having inflammation at a cerebral blood vessel thereof, comprising a step of making CD4 positive T cells exist in the body of a non-human animal being under stress condition, wherein the CD4 positive T cells are reactive to an antigen derived from the central nervous tissue.
A disease modeling non-human animal having inflammation at a blood vessel in the boundary area of the third ventricle, thalamus, and dentate gyrus thereof, and having at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder, and sudden death.
A method for screening a drug for preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder, and sudden death, comprising:
7-14. (canceled)
Dependencies are inferred from the claim text.