Integrated multi-electrode array and trans-endothelial electrical resistance in organ-on-a-chip microsystems

A device, comprising:

• a) a body having a first microchannel and a second microchannel;
• b) a membrane located between the first microchannel and the second microchannel;
• c) at least one transendothelial electrical resistance electrode aligned along the first or second microchannel, the at least one transendothelial electrical resistance electrode having a platinum black coating;
• and
• d) a platform under the second microchannel, the platform having a multi-electrode array.

A device, comprising:

• a) a fluidic channel having at least two fluidic ports;
• b) electrically-active cells adhered within the fluidic channel;
• and
• b) an electrode having a platinum black coating, the electrically-active cells being on the electrode.

A method, comprising:

• a) providing a device having
• i) a fluidic channel with at least two fluidic ports,
• ii) an electrode having a platinum black coating, and
• iii) a cell culture media within the fluidic channel;
• and
• b) seeding electrically-active cells within the fluidic channel.