Trapped ion mobility spectrometer with high ion storage capacity
AssigneeBruker Daltonik GmbH
InventorsOliver RÄTHER, Thomas BETZ, Melvin Andrew PARK
Life of this patent
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Abstract
The invention is related to a trapped ion mobility spectrometer (TIMS device) and proposes to use higher order (order N>2) linear multipole RF systems to accumulate and analyze ions at an electric DC field barrier, either pure higher order RF multipole systems or multipole RF systems with transitions from higher order towards lower order, e.g. from a linear octopolar RF system (N=4) to a linear quadrupole RF system (N=2) in front of the apex of the electric DC field barrier.
Claims9
A trapped ion mobility analyzer comprising an RF ion guide, an electric DC field barrier and a counteracting gas flow that drives ions against the electric DC field barrier, wherein an RF field of the RF ion guide transitions from an RF field of an ion guide with stacked apertured electrodes into a quadrupolar RF field.
A mass spectrometric system comprising a trapped ion mobility analyzer and a downstream mass analyzer,
- wherein the trapped ion mobility analyzer comprises an RF ion guide, an electric DC field barrier and a counteracting gas flow that drives ions against the electric DC field barrier, and
- wherein an RF field of the RF ion guide transitions from an RF field of an ion guide with stacked apertured electrodes into a quadrupolar RF field.
A method for operating a trapped ion mobility analyzer, comprising the steps of:
- (a) generating ions in an ion source;
- (b) transferring the ions into an RF ion guide;
- (c) radially confining the ions in the RF ion guide by an RF field which transitions from an RF field of an ion guide with stacked apertured electrodes into a quadrupolar RF field;
- (d) axially trapping the ions in the RF ion guide by an electric DC field barrier and a counteracting gas flow that drives the ions against the electric DC field barrier;
- and
- (e) releasing the trapped ions from the RF ion guide according to their mobility by changing the electric DC field barrier and/or the gas flow.
Dependencies are inferred from the claim text.