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US 2020/0048666 A1Published application
Microorganisms and methods for the production of fatty acids and fatty acid derived products
AssigneeCargill, Incorporated
InventorsMichael LYNCH, Michael LOUIE, Shelley COPLEY, Eileen SPINDLER, Brittany PRATHER, Matthew LIPSCOMB, Tanya LIPSCOMB, Hans LIAO, Dave HOGSETI, Ron EVANS
Life of this patent
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Abstract
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.
Claims19
1-42. (canceled)
A genetically modified organism comprising:
- a heterologous nucleic acid encoding a first NphT7 polypeptide;
- and
- a heterologous nucleic acid encoding a second NphT7 polypeptide, the second NphT7 polypeptide comprising one or more amino acid substitutions at a position selected from the group consisting of Ser84, Thr85, Gln90, Val114, Tyr144, Ile147, Val157, Phe159, Ile194, Val196, Phe217, Gly288, and Gly318,
- wherein said microorganism produces a fatty acid or fatty acid-derived product having a carbon chain length of C6 or greater.
1 more element
Dependencies are inferred from the claim text.