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US 2020/0048635 A1Published application
METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs
AssigneeWashington University
InventorsTimothy M. Miller, Mariah Lawler, Ted Hyman, Erica Koval, Joseph Dougherty
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Abstract
The present invention relates to compositions and methods for detecting motor neuron-specific miRNAs in a population of cells or subject. More particularly, the invention relates to detecting motor neuron-specific miRNAs to detect and treat motor neuron diseases associated with dysregulation of motor neuron-specific miRNAs, such as Amyotrophic Lateral Sclerosis (ALS).
Claims16
A method to detect motor neuron disease, the method comprising:
- measuring the amount of miR-218 in a biological sample obtained from a subject, and comparing the amount of miR-218 in the biological sample to a reference value, wherein dysregulation of miR-218 relative to the reference value indicates motor neuron disease.
A method to detect the efficacy of treatment or the progression of motor neuron disease, the method comprising:
- a. measuring the amount of miR-218 in a first biological sample obtained from a subject;
- b. then at a later time measuring the amount of miR-218 in a second biological sample obtained from a subject;
- and
- c. comparing the amount of miR-218 in the first biological sample to the amount of miR-218 in the second biological sample, wherein a change in miR-218 indicates effectiveness of treatment or progression of motor neuron disease.
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Dependencies are inferred from the claim text.