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US 2020/0048627 A1Published application
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki IGAWA, Shinya ISHII, Atsuhiko MAEDA, Takashi NAKAI
Life of this patent
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Abstract
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
Claims3
1-50. (canceled)
An antibody that is capable of binding to human IL-6 and comprises
- (a) a heavy chain having the amino acid sequence of SEQ ID NO:
- 62 and a light chain having the amino acid sequence of SEQ ID NO:
- 63;
- (b) a heavy chain having the amino acid sequence of SEQ ID NO:
- 64 and a light chain having the amino acid sequence of SEQ ID NO:
- 65;
- or
- (c) a heavy chain having the amino acid sequence of SEQ ID NO:
- 64 and a light chain having the amino acid sequence of SEQ ID NO:
- 66.
7 more elements
An antibody that is capable of binding to mouse IL-31 receptor and comprises
- (a) a heavy chain having the amino acid sequence of SEQ ID NO:
- 67 and a light chain having the amino acid sequence of SEQ ID NO:
- 68;
- or
- (b) a heavy chain having the amino acid sequence of SEQ ID NO:
- 69 and a light chain having the amino acid sequence of SEQ ID NO:
- 68.
4 more elements
Dependencies are inferred from the claim text.