Archaeal pyrrolysyl trna synthetases for orthogonal use
AssigneeEuropean Molecular Biology Laboratory
InventorsEdward Lemke, Ivana Nikic, Gemma Estrada Girona, Christine Köhler
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Abstract
The invention relates to archaeal pyrrolysyl tRNA synthetases lacking a nuclear localization signal and/or comprising a nuclear export signal. The invention also relates to polynucleotides encoding said pyrrolysyl tRNA synthetases, eukaryotic cells comprising said polynucleotide and tRNA acylated by the pyrrolysyl tRNA synthetase or a polynucleotide encoding such tRNA, methods utilizing said cells for preparing polypeptides comprising unnatural amino acid residues, and kits useful in said methods.
Claims13
An archaeal pyrrolysyl tRNA synthetase that lacks a nuclear localization signal and/or comprises a nuclear export signal.
Dependencies are inferred from the claim text.