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AssigneeChristopher B. Reid
InventorsChristopher B. REID, Melissa BRAGA, Lilian N. SANTAMARIA, Ashley N. WICKREMA, Marinne D. WICKREMA, Anthony HAO DINH, Yaman EKSIOGLU, Mat HOANG HO
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The claimed invention is directed towards a novel combination cell electroporation/cell culturing apparatus which can be termed a cell culture dish suitable for in vitro electroporation, and towards a device suitable for in vivo electroporation—both useful in methods suitable for the generation of developmentally-activated, pluripotent, pluripotent-like, multipotent, and/or self-renewing cells which are capable of beginning to differentiate in culture into a variety of cell types and capable of further differentiation in vivo. The claimed invention is also directed towards the generation of desirable, differentiating somatic cell populations transplantable to animals or patients, genetic modification of endogenous and exogenous cells, and the treatment of patients suffering from diseases that may be ameliorated by these methods. This invention also provides methods for preventing, treating, or retarding disease, for example, immunodeficiency virus (e.g. HIV-1, HIV-2, SIV, FIV, etc.) infection.
A cell or tissue culture system comprising one or more first compartment with dimensions for electroporation, the one or more first compartment permitting communication with a second compartment that permits incubation and/or comprises an inspection or visualization plane for microscopic observation, and wherein the cell or tissue culture system is configured to permit one or more cells electroporated in the one or more first compartment in a first medium to be incubated and cultured in the second compartment in a second medium, thereby eliminating infectious and contamination risks associated with transfer of cells between a cell or tissue culture system/and a distinct electroporation apparatus, and wherein, the one or more first compartment is
Dependencies are inferred from the claim text.