Organic compounds

A method of preparing a perfume composition adapted to address sleep quality, said method comprising the steps of:

• measuring the brain wave activity of a human subject after inhaling said perfume composition by electroencephalography (EEG) using the standard 10-electrode system;
• determining the Sandman Classifier (SC) according to the following formula
• SC=((a1ce+Θce)/δtem)+(Θ/a2)
• wherein:
• a1ce represents the amplitude value of alpha-1 brain wave activity with a frequency of oscillation between 8-12 hertz over the central electrodes C3, C4, Cz
• Θce represents the amplitude value of theta brain wave activity with a frequency of oscillation between 4-7 Hertz over the central electrodes C3, C4, Cz
• δtem represents the amplitude value of theta brain wave activity with a frequency of oscillation between 0.1-3 Hz over the temporal electrodes T7 and T8;
• and
• Θ/a2 represents the ratio of the amplitude of theta brain wave activity with a frequency of oscillation between 4-7 Hertz over the amplitude value of alpha-2 brain wave with a frequency of oscillation between 12-15 hertz, across all electrodes;
• and
• combining functional perfume ingredients in a manner such that said combination has a Sandman Classifier value greater than 1.35.

A method of determining the Sandman Classifier (SC) of a perfume composition, comprising the steps of:

• measuring the brain wave activity of a human subject after inhaling said perfume composition by electroencephalography (EEG) using the standard 10-electrode system;
• and
• determining the Sandman Classifier (SC) according to the following formula
• SC=((a1ce+Θce/δtem)+(Θ/a2)
• wherein:
• a1ce represents the amplitude value of alpha-1 brain wave activity with a frequency of oscillation between 8-12 hertz over the central electrodes C3, C4, Cz
• Θce represents the amplitude value of theta brain wave activity with a frequency of oscillation between 4-7 Hertz over the central electrodes C3, C4, Cz
• δtem represents the amplitude value of theta brain wave activity with a frequency of oscillation between 0.1-3 Hz over the temporal electrodes T7 and T8;
• and
• Θ/a2 represents the ratio of the amplitude of theta brain wave activity with a frequency of oscillation between 4-7 Hertz over the amplitude value of alpha-2 brain wave with a frequency of oscillation between 12-15 hertz, across all electrodes.