Thermosensitive phosphazene-based polymer comrising sulfonated moiety, and preparation method and use thereof

A thermosensitive phosphazene-based polymer comprising a sulfate group,

• wherein a first moiety of an amino acid ester represented by Formula 2 below;
• a second moiety of polyethyleneglycol represented by Formula 3 below;
• and
• a third moiety including a sulfate group linked directly or by a linker,
• are linked to a phosphorous atom of a polyphosphazene backbone represented by Formula 1 below,
• in a molar ratio of a:b:c respectively by —O— or —NH—:
• wherein a is 55 mol % to 75 mol %, b is 5 mol % to 30 mol %, and c is 0.5 mol % to 20 mol %,
• in Formulae 1, 2, and 3,
• R1 is C1-6 alkyl, C1-6 alkenyl, or C6-10 aryl-C1-6 alkyl;
• R2 is hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, thiomethyl, methylthioethyl, benzyl, hydroxybenzyl, or 2-indolylmethyl;
• R3 is C1-6 alkyl;
• n is an integer of 3 to 100,000;
• and
• p is an integer of 1 to 20.