Heterodimeric proteins
AssigneeXencor, Inc.
InventorsGregory Moore, Rumana Rashid, John Desjarlais
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Abstract
The present invention describes novel immunoglobulin compositions that co-engage at least two antigens, e.g. a first and second antigen, or, as outlined herein, three or four antigens can be bound, in some of the scaffold formats described herein. First and second antigens of the invention are herein referred to as antigen-1 and antigen-2 respectively (or antigen-3 and antigen-4, if applicable. As outlined herein, a number of different formats can be used, with some scaffolds relying combinations of monovalent and bivalent bindings.
Claims11
-54. (canceled)
A composition comprising a heterodimeric protein comprising a heterodimeric Fc domain, said heterodimeric Fc domain comprising:
- a) a first monomer comprising-a first variant Fc domain comprising amino acid substitutions S239D, 332E, L368E, K370S;
- and
- b) a second monomer comprising-a second variant Fc domain comprising amino acid substitutions S239D, 332E, S364K, and M428L, wherein numbering is according to the EU index as in Kabat and wherein said first variant Fc domain and said second variant Fc domain are variant human IgG Fc domains.
Dependencies are inferred from the claim text.