Pharmaceutical composition
AssigneeUcb Biopharma Sprl
InventorsAndrew Jeffrey YATES, Jan Ivo MASSANT
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical compositions comprising an antibody or a fragment thereof suitable for freeze-drying (i.e. lyophilizing). The pharmaceutical compositions, which comprise an antibody or an antigen-binding fragment thereof; from 1% to 20% w/v sucrose; an amino acid or a mixture of amino acids; and surfactant, are provided as pharmaceutical compositions for freeze-drying; as freeze-dried (i.e. lyophilized) compositions which can be reconstituted into a solvent at the time of use or as reconstituted liquid formulations ready for administration.
Claims22
A pharmaceutical composition comprising:
- a. an antibody or an antigen-binding fragment thereof;
- b. from 1% to 20% w/v sucrose;
- c. an amino acid or a mixture of amino acids;
- d. a surfactant;
- and
- e. optionally a pH of from 4.0 to 7.5.
(canceled)
A freeze-dried formulation comprising an antibody or an antigen-binding fragment thereof, sucrose, an amino acid or a mixture of amino acids, and optionally a surfactant, wherein the formulation comprises from 10% to 40% w/w sucrose.
(canceled)
A freeze-dried formulation comprising an antibody or an antigen-binding fragment thereof comprising a light variable region as defined in SEQ ID NO:
- 7 and a heavy variable region as defined in SEQ ID NO:
- 8 and from 10% to 40% w/w sucrose.
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22-27. (canceled)
Dependencies are inferred from the claim text.