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AssigneesMedImmune, LLC, Humabs Biomed SA
InventorsCHRISTINE TKACZYK, BRET SELLMAN, MARTIN BORROK, III, DAVIDE CORTI, ANDREA MINOLA
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The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.
An antibody or antigen-binding fragment thereof that specifically binds to a Staphylococcus aureus (S. aureus) clumping factor A (ClfA) protein, wherein said antibody or antigen-binding fragment comprises a variable heavy chain (VH) complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO:
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An antibody or antigen-binding fragment thereof that specifically binds to a S. aureus ClfA protein, wherein said antibody or antigen-binding fragment comprises (1) a VH, (2) a VL, and (3) a heavy chain constant domain comprising the amino acid sequence of CSYHLC (SEQ ID NO:
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A bispecific antibody or antigen-binding fragment thereof that specifically binds to a S. aureus ClfA protein and specifically binds to a S. aureus alpha toxin (AT) protein, wherein the antibody or antigen-binding fragment comprises a VH CDR1 comprising the amino acid sequence of SEQ ID NO:
20-24. (canceled)
An antibody or antigen-binding fragment thereof that specifically binds to a S. aureus ClfA protein, wherein said antibody or antigen-binding fragment comprises the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3 of SAR114, SAR72, SAR80, SAR113, SAR132, SAR352, SAR372, SAR510, SAR547, SAS1, SAS19, or SAS203.
(canceled)
An antibody or antigen-binding fragment thereof that specifically binds to a S. aureus ClfA protein, wherein said antibody or antigen-binding fragment comprises a VH and a VL, wherein the VH comprises the amino acid sequence set forth in SEQ ID NO:
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70-71. (canceled)
Dependencies are inferred from the claim text.