Method of identifying musk compounds
AssigneeFirmenich SA
InventorsPatrick PFISTER, Matthew ROGERS
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Abstract
Provided herein are polypeptides that bind to Musk compounds. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that activates, mimics, blocks, inhibits, modulates, and/or enhances the activity of an olfactory receptor that is activated by a polycyclic Musk or a nitro Musk wherein the receptor is a polypeptide having an amino acid sequence that is at least 75% identical to Olfr96 or OR11A1, wherein the method includes a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor.
Claims18
A host cell transformed to express a polypeptide comprising an amino acid sequence that is at least 75% identical to SEQ ID NO:
- 2 or SEQ ID NO:
- 4.
(canceled)
An expression vector comprising
- a) a nucleic acid that encodes for a polypeptide comprising an amino acid sequence that is at least 75%, 80%, 85%, 90%, 95%, 98% or 99% identical to SEQ ID NO:
- 2 or SEQ ID NO:
- 4;
- or
- b) a nucleic acid that comprises a nucleotide sequence that is at least 75%, 80%, 85%, 90%, 95%, 98% or 99% identical to SEQ ID NO:
- 1 or SEQ ID NO:
- 3.
6-9. (canceled)
11-12. (canceled)
(canceled)
20-25. (canceled)
A method for identifying a musk compound, comprising utilizing a polypeptide having an amino acid sequence that is at least 75% identical to SEQ ID NO:
- 2 or SEQ ID NO:
- 4 in a receptor based assay for identifying a musk compound.
Dependencies are inferred from the claim text.