US 2020/0048309 A1Published application

Multivalent ligand-lipid constructs

OwnerNicolai Vladimirovich BOVIN, Stephen Micheal HENRY +3inventors

InventorsNicolai Vladimirovich BOVIN, Stephen Micheal HENRY, Elena KORCHAGINA, Igor Leonidovich RODIONOV, Alexander Borisovich TUZIKOV

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Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.

Dependent claims

1) A construct of the structure:

where F is an oligopeptide comprising an N-maleoyl-β-alanine conjugated Cys residue, L is a conjugated phosphatidylethanolamide and S is a tetraantennary spacer of the structure:
where m is the integer 1, 2 or 3 and R is of the structure:
where M is a monovalent cation or substituent, n is the integer 2, 3, 4, 5, 6 or 7, and * is the point of attachment of F or L.

Dependencies are inferred from the claim text.

C07K 9/00
Peptides having up to 20 amino acids, containing saccharide radicals and having
A61K 31/685
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols: one of the hydroxy compounds having nitrogen atoms, e.g.…
A61K 31/7004
Carbohydrates; Sugars; Derivatives thereof: monosaccharides having only carbon, hydrogen and oxygen atoms
A61K 31/7016
Carbohydrates; Sugars; Derivatives thereof: disaccharides, e.g. lactose, lactulose

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