Methods for removing bacterial toxins from a biological fluid
AssigneeSetlance S.R.L.
InventorsAlessandro Pini, Chiara Falciani, Luisa Bracci, Jlenia Brunetti, Leila Quercini
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Abstract
This invention relates to methods for removing bacterial toxins such as lipopolysaccharide and lipoteichoic acid from a biological fluid. In such method a peptide, selected from the list of KKIRVRLSA, RRIRVRLSA, KRIRVRLSA and RKIRVRLSA, is covalently attached to a solid support through its C-terminus, optionally with the interposition of a linker, and is used to capture the toxins. This invention also relates to such derivatised solid supports and to cartridges, columns, and medical apparatuses comprising such derivatised solid supports.
Claims15
A method for removing bacterial toxins selected from the list of LPS and LTA from a biological fluid, said method comprising contacting the biological fluid with a peptide selected from the list of KKIRVRLSA, RRIRVRLSA, KRIRVRLSA and RKIRVRLSA which is covalently attached to a solid support through its C-terminus, optionally with the interposition of a linker, whereby a linker-peptide moiety is formed and wherein all amino acids of the peptide are either in the L- or the D-configuration.
A solid support which is covalently attached to the C-terminus of a peptide selected from the list of KKIRVRLSA, RRIRVRLSA, KRIRVRLSA and RKIRVRLSA, optionally with the interposition of a linker, whereby a peptide-linker moiety is formed.
(canceled)
Dependencies are inferred from the claim text.