Glutathione-cholesterol derivatives as brain targeting agents

A kit comprising:

• a) a blood brain barrier permeable composition, wherein the composition comprises a molecule as set forth in:
• (i) formula (I), (II), (III), (IV), (V), (VI), (VII), or (VIII):
• wherein R1=OH, O-alkyl (1 to 30 C), O-aryl (6-30 C), O-aryl and O-alkyl combinations (6-30 C), S-alkyl (1-30 C), S-aryl (6-30 C), S-aryl and S-alkyl combinations (6-30 C), N-alkyl (1-30 C), N-aryl (6-30 C), or N-aryl and N-alkyl combinations (6-30 C), combinations thereof;
• R2=OH, O-alkyl (1-30 C), O-aryl (6-30 C), O-aryl and O-alkyl combinations (6-30 C), S-alkyl (1-30 C), S-aryl (6-30 C), S-aryl and S-alkyl combinations (6-30 C), N-alkyl (1-30 C), N-aryl (6-30 C), or N-aryl and N-alkyl combinations (6-30 C), and combinations thereof;
• R3=H, alkyl (1-30 C), aryl (6-30 C), or aryl and alkyl combinations (6-30 C),
• R4=H, alkyl (1-30 C), aryl (6-30 C), or aryl and alkyl combinations (6-30 C), and
• the linker includes alkyl, aliphatic chain, alkoxy and combinations thereof, wherein the composition does not fluoresce in the absence of an exogenous fluorescing compound or
• (ii) a blood brain barrier permeable composition, wherein the composition comprises a molecule as set forth in formula (I), (II), (III), (IV), (V), (VI), (VII), or (VIII):
• wherein R1=R2=OH, O-alkyl (1-30 C), O-aryl (6-30 C), O-aryl and O-alkyl combinations (6-30 C), S-alkyl (1-30 C), S-aryl (6-30 C), S-aryl and S-alkyl combinations (6-30 C), N-alkyl (1-30 C), N-aryl (6-30 C), or N-aryl and N-alkyl combinations (6-30 C), and combinations thereof;
• wherein R3=R4=H, alkyl (1-30 C), aryl (6-30 C), or aryl and alkyl combinations (6-30 C), and
• the linker includes alkyl, aliphatic chain, alkoxy and combinations thereof, wherein the composition forms micelles;
• b) optionally, one or more compounds selected from phospholipids, cholesterol or buffers;
• c) one or more agents selected from the group consisting of buffers, dyes, fluorescent agents, drugs, chemotherapeutics, nutraceuticals, vitamins, nucleic acids, proteins, antigens, antibodies buffer, a hydrophobic agent, a therapeutic agent, an antioxidant, an anti-inflammatory drug, an anticancer drug, a cosmetic, a pharmaceutical, a pesticide, an insecticide, an herbicide, an antiseptic, a diagnostic agent, a food additive, a fragrance, and a textile and combinations thereof;
• d) instructions reciting a method for producing a composition comprising a liposome or micelle and said one or more agents;
• e) a label;
• and
• f) a container comprising components (a)-(e).