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US 2020/0048295 A1Published application
Hydrated and anhydrous polymorphs of 2'-o-fucosyllactose and their production methods
AssigneeBASF SE
InventorsGiovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
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Abstract
This invention describes new hydrated and anhydrous polymorphs of 2′-O-fucosyllactose (2′FL): Polymorph A 2′FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
Claims27
-23. (canceled)
A method for obtaining crystalline 2′-O-Fucosyllactose (2′FL), the method comprising:
- providing 2′FL in an aqueous solution comprising (i) water and (ii) the 2′FL dissolved therein;
- adding a crystallization solvent to the aqueous solution over a period of 1 hr to 15 hr, thereby crystallizing the 2′FL and forming 2′FL crystals suspended in the aqueous solution;
- separating the 2′FL crystals from the aqueous solution to collect solid 2′FL crystals;
- and
- drying the solid 2′FL crystals.
2 more elements
A method for obtaining crystalline 2′-O-Fucosyllactose (2′FL) hydrate in form of polymorph B with molecular formula C18H32O15.nH2O wherein n is 5/2, the method comprising:
- providing 2′FL in an aqueous solution comprising (i) water and (ii) the 2′FL dissolved therein;
- warming and agitating the aqueous solution at a temperature in range of 30° C. to 60° C. for 1 hr to 12 hr;
- maintaining the aqueous solution at a temperature in range of 20° C. to 30° C. for 10 hr to 240 hr, thereby crystallizing the 2′FL and forming 2′FL hydrate in form of polymorph B crystals suspended in the aqueous solution;
- separating polymorph B crystals from the aqueous solution to collect solid polymorph B crystals;
- and
- drying the solid polymorph B crystals.
3 more elements
Dependencies are inferred from the claim text.