Platinum (ii) complexes containing n-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment
AssigneeThe University of Hong Kong
InventorsChi Ming CHE, Sin Ki FUNG, Tian Feng CHEN
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Abstract
Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
Claims10
A Pt(II) complex consisting of a Pt(II)-N-heterocyclic carbene (“NHC”) ligand and 1, 3-bis(2-pyridylimino) isoindoline (BPI) ligand, and wherein the Pt(II) complex has formula I,
- wherein R1 is —CH3, —C4H9, -nC6H13, —CH3, or —CH2Ph, and
- wherein R2 is —CH3, —C4H9, -nC6H13, —C8H17, —C16H33, or —CH2Ph.
(canceled)
A Pt(II) complex consisting of a Pt(II)-NHC ligand and 1, 3-bis(2-pyridylimino) isoindoline (BPI) ligand, wherein the Pt(II)-NHC ligand is perpendicular to the BPI ligand, and having the following formula:
- wherein R1 is —CH3, —C4H9, -nC6H13, —CH3, or —CH2Ph, and
- wherein R2 is —CH3, —C4H9, -nC6H13, —C8H17, —C16H33, or —CH2Ph.
10-18. (canceled)
Dependencies are inferred from the claim text.