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US 2020/0048279 A1Published application
Compounds useful for inhibiting ror-gamma-t
AssigneeEli Lilly and Company
InventorsChristian Alexander Clarke, Charles Willis Lugar, III, John Richard Morphy, Timothy Ivo Richardson, Helene Rudyk, Selma Sapmaz, Ryan Edward Stites, Grant Mathews Vaught
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Abstract
The present invention provides novel ROR gamma-t inhibitors and pharmaceutical compositions thereof, formula (A).
Claims23
A compound of formula
- wherein
- n is 0, 1, or 2;
- X is independently —N— or —CH—;
- R1 is —C1-3 alkyl;
- R2 is —H or —CH3;
- R3a and R3b are independently —H, —CH3, or —CH2CH3;
- R4 is
- or thiazolyl optionally substituted with —CF3;
- R5 is halo, —CN, —CF3, oxadiazolyl, or oxadiazolyl optionally substituted with CH3,
- R6 is —H, —OMe, halo, —CH3, or —CF3;
- provided that when n is 0, X is —N, —R1 is —CH2CH3, R2 is —CH3 in the position adjacent to the —O—, R3a and R3b are —H and —CH3, then R5 cannot be —CF3;
- or a pharmaceutically acceptable salt thereof.
9 more elements
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Dependencies are inferred from the claim text.