Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof

An aminopyrimidine five-membered heterocyclic compound represented by formula I-1, a pharmaceutically acceptable salt, a tautomer, an enantiomer or a diastereomer or a prodrug thereof:

• wherein, “” represents for a single bond or a double bond;
• when“” is a single bond, Z is N or CR5;
• R5 is H, D or C1-C20 alkyl;
• when“” is double bond, Z is C;
• X is O, CO or NR3;
• Y is CO, CH2 or NR4;
• each of R1 and R2 is independently selected from substituted or unsubstituted C1-C20 alkyl, substituted or unsubstituted C6-C30 aryl or substituted or unsubstituted C2-C30 heteroaryl;
• the C2-C30 heteroaryl in the substituted or unsubstituted C2-C30 heteroaryl refers to a C2-C30 heteroaryl that comprising 1-4 heteroatoms which is selected from the group consisting of N, O or S;
• the substituent in the substituted C1-C20 alkyl group, the substituted C6-C30 aryl or the substituted C2-C30 heteroaryl is selected from one or more of the group consisting of one or more halogens, C1-C120 alkyl, halogenated C1-C20 alkyl, oxo, hydroxyl, amino,
• cyano, C1-C20 alkoxyl, halogenated C1-C20 alkoxyl and C1-C20 alkylthio;
• when the number of the substituent is more than one, the substituents are the same or different;
• wherein, each of Ra and Rb is independently H or C1-C20 alkyl;
• Rc is C1-C20 alkyl;
• R3 is H, C1-C20 alkyl or C3-C30 cycloalkyl;
• R4 is H, C1-C20 alkyl or C3-C30 cycloalkyl;
• m is 0, 1, 2 or 3;
• n is 0, 1, 2 or 3.