[1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
AssigneeJanssen Pharmaceutica NV
InventorsYves Emiel Maria Van Roosbroeck, Petrus Jacobus Johannes Antonius Buijnsters, Gary John Tresadern, Edgar Jacoby, Daniel Oehlrich, Henricus Jacobus Maria Gijsen
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.
Claims18
A compound having the Formula (I)
- or a stereoisomeric form thereof, wherein
- R1 is CHF2 or CH3;
- A is a radical selected from (a-1) and (a-2)
- wherein
- R2 is selected from 2-pyridyl, 1-isoquinolinyl, 4-quinazolinyl, 1H-pyrrolo[3,2-c]-pyridin-4-yl, and furo[3,2-c]pyridin-4-yl;
- each of which is optionally substituted with 1 or 2 substituents each independently selected from the group consisting of halo, OH, —CN;
- C1-4alkyl optionally substituted with 1, 2 or 3 independently selected halo substituents;
- C1-4 alkyloxy optionally substituted with 1, 2 or 3 independently selected halo substituents;
- and 1-morpholinyl;
- or a pharmaceutically acceptable salt or a solvate thereof.
(canceled)
(canceled)
A method of treatment according to claim 15, wherein
- the psychotic disorders are selected from the group of schizophrenia;
- schizophreniform disorder;
- schizoaffective disorder;
- delusional disorder;
- substance-induced psychotic disorder;
- personality disorders of the paranoid type;
- and personality disorder of the schizoid type;
- the anxiety disorders are selected from the group of panic disorder;
- agoraphobia;
- specific phobia;
- social phobia;
- obsessive-compulsive disorder;
- post-traumatic stress disorder;
- acute stress disorder;
- and generalized anxiety disorder;
- the movement disorders are selected from the group of Huntington's disease and dyskinesia;
- Parkinson's disease;
- restless leg syndrome and essential tremor;
- Tourette's syndrome and other tic disorders;
- the substance-related disorders are selected from the group of alcohol abuse;
- alcohol dependence;
- alcohol withdrawal;
- alcohol withdrawal delirium;
- alcohol-induced psychotic disorder;
- amphetamine dependence;
- amphetamine withdrawal;
- cocaine dependence;
- cocaine withdrawal;
- nicotine dependence;
- nicotine withdrawal;
- opioid dependence and opioid withdrawal;
- the mood disorders are selected from depression;
- mania;
- bipolar I disorder, bipolar II disorder;
- cyclothymic disorder;
- dysthymic disorder;
- major depressive disorder;
- treatment-resistant depression;
- and substance-induced mood disorder;
- the neurodegenerative disorders are selected from the group of Parkinson's disease;
- Huntington's disease;
- dementia;
- Alzheimer's disease;
- multi-infarct dementia;
- AIDS-related dementia or frontotemperal dementia;
- the disorders or conditions comprising as a symptom a deficiency in attention and/or cognition are selected from the group of dementia associated with Alzheimer's disease;
- multi-infarct dementia;
- dementia due to Lewy body disease;
- alcoholic dementia or substance-induced persisting dementia;
- dementia associated with intracranial tumours or cerebral trauma;
- dementia associated with Huntington's disease;
- dementia associated with Parkinson's disease;
- AIDS-related dementia;
- dementia due to Pick's disease;
- dementia due to Creutzfeldt-Jakob disease;
- delirium;
- amnestic disorder;
- post-traumatic stress disorder;
- stroke;
- progressive supranuclear palsy;
- mental retardation;
- a learning disorder;
- attention-deficit/hyperactivity disorder (ADHD);
- mild cognitive impairment;
- Asperger's syndrome;
- age-related cognitive impairment;
- and cognitive impairment related to perception, concentration, learning or memory;
- and
- the disorders related to memory acquisition and consolidation are selected from memory disorders.
(canceled)
(canceled)
Dependencies are inferred from the claim text.