Kdm5 inhibitors

A compound of formula I

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is
• halogen,
• C1-C6 alkyl, unsubstituted or substituted with CF3,
• C2-C3 alkylene-C(O)—O—C1-C6 alkyl,
• a 3-, 4-, 5- or 6 membered saturated carbocycle, or
• a 6-membered unsaturated carbocycle;
• R2 is
• halogen,
• CF3,
• C1-C6 alkyl,
• C2-C4 alkenylene-O—C1-C3 alkyl,
• C(O)—O—C1-C6 alkyl,
• C(═CH2)C1-C4 alkyl,
• C2-C4 alkenylene C6H5,
• C1-C4 alkylene C6H5,
• a 3-, 4-, 5- or 6 membered saturated carbocycle,
• a 6-membered unsaturated carbocycle, unsubstituted or mono-substituted or independently di-substituted with R3,
• a 6-membered saturated heterocycle, unsubstituted, having 1 heteroatom which is O,
• a 5-membered unsaturated heterocycle having 1 or 2 heteroatoms independently selected from N, O and S, unsubstituted or independently mono- or di-substituted with R5, or
• a 6-membered unsaturated heterocycle, having 1 or 2 heteroatoms independently selected from N and O, unsubstituted or independently mono-, di-, tri- or tetra-substituted with R4, or
• an 8-, 9-, or 10-membered unsaturated bicyclic heterocycle having 1, 2 or 3 heteroatoms independently selected from N or O, unsubstituted or substituted with R6;
• R3 is
• —C1-C3 alkyl, unsubstituted or mono- or independently di-substituted with a 6-membered saturated heterocycle having 1 or 2 heteroatoms independently selected from N and O, —C(O)OC1-C3 alkyl, —OH, —CF3, and CN,
• C1-C3 alkoxy,
• halogen,
• CN,
• OH,
• O—C6H5,
• OC1-C3 alkyl,
• C(O)OC1-C3 alkyl,
• CF3,
• C(O)N(CH3)2,
• NH2,
• NHSO2C1-C3 alkyl,
• NH(C1-C3 alkyl),
• N(C1-C3 alkyl)(C1-C3 alkyl),
• NHSO2 cC3H5,
• a 5- or 6-membered saturated heterocycle having 1 or 2 heteroatoms independently selected from N, O and S, wherein S is a dioxide, unsubstituted or substituted with C1-C3 alkyl, or
• a 5- or 6-membered unsaturated heterocycle, unsubstituted or substituted with C1-C3 alkyl, having 1, 2 or 3 N atoms;
• R4 is
• halogen,
• C1-C3 alkyl, unsubstituted or substituted with —OH,
• CN,
• CF3,
• cC3H5,
• CF2CH2OH,
• a 6-membered saturated heterocycle having 1 or 2 heteroatoms independently selected from N and O, or
• a 5-membered unsaturated heterocycle having 2 N atoms;
• R5 is
• CF3,
• C1-C5 alkyl, unsubstituted or substituted with a 6-membered saturated heterocycle having 1 or 2 heteroatoms independently selected from N and O, a 6-membered unsaturated carbocycle, a 6-membered unsaturated heterocycle having 1 N atom, —OC1-C4 alkyl, —OH, —C(O)OH, a 5-membered unsaturated heterocycle having 1 S atom, cC3H5, —SO2C1-C4 alkyl, —NHC1-C4 alkyl, or a 3-5-membered saturated carbocycle unsubstituted or substituted with F,
• a 3-, 4-, 5- or 6-membered saturated carbocycle,
• a 6-membered unsaturated carbocycle unsubstituted or substituted with halogen,
• a 6-membered saturated heterocycle having 1 or 2 heteroatoms independently selected from N and O, or
• a 5-membered unsaturated unsubstituted heterocycle having 1 or 2 N heteroatoms;
• and
• R6 is C1-C6 alkyl, cyclopropyl or ═O.