US 2020/0048254 A1Published application

Toll-like receptor 7 (tlr7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor

AssigneeBristol-Myers Squibb Company

InventorsLiqi HE, Sanjeev GANGWAR, Shoshana L. POSY, Yam B. POUDEL, Prasanna SIVAPRAKASAM

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Abstract

Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

Claims1

Dependent claims

A compound having a structure according to formula (Ia-01):

Dependencies are inferred from the claim text.

Facts

Application: 16/659,735Filed 22 Oct 2019
Priority: 16 Aug 2017
Published: 13 Feb 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 473/18
With oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6: one oxygen and one nitrogen atom, e.g. guanine
A61K 31/52
Ortho- or peri-condensed with heterocyclic rings: purines, e.g. adenine
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61K 47/6803
Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent: drugs conjugated to an antibody or…

Family

Application62/546,211Us provisional application · filed 16 Aug 2017
Application16/103,601Continuation · filed 14 Aug 2018
Application16/659,735Continuation
US 10,487,084 B2Related patent
US 10,711,003 B2Related patent
US 2019/0055246 A1Published application
US 2020/0048254 A1This patent

From the US filing history. Foreign family members aren’t listed.

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