Ptpn11 inhibitors

A compound represented by Formula I

• or a salt, ester, or prodrug thereof, wherein:
• subscript a is 0 or 1;
• subscript b is 0 or 1;
• Y1 is a direct bond or CR17R18;
• Y2 is selected from the group consisting of C1-4alkyl, amino, C1-4alkylC(O)O—, C1-4alkylamino and C1-4aminoalkyl;
• R1 is selected from the group consisting of C6-10aryl, C3-8cycloalkyl, C3-8cycloalkenyl, and a 5-10 membered heteroaryl group having 1 to 4 heteroatoms or groups as ring vertices independently selected from N, C(O), O, and S;
• said aryl or heteroaryl of R1 is optionally substituted with 1 to 5 R12 groups independently selected from the group consisting of halo, hydroxy, amino, C1-4alkylamino, di(C1-4alkyl)amino, cyano, C1-4alkyl, C1-4alkoxy, C1-4hydroxyalkyl, C1-4haloalkyl, C1-4aminoalkyl, C3-8cycloalkyl, C3-8cycloalkenyl, NR15C(O)R14, NR15C(O)OR14, NR14C(O)NR15R16, NR15S(O)R14, NR15S(O)2R14, C(O)NR15R16, S(O)NR15R16, S(O)2NR15R16, C(O)R14, C(O)OR14, OR14, SR14, S(O)R14, and S(O)2R14;
• R2, R3, R10, and R11 are each independently selected from the group consisting of hydrogen, C1-4alkyl, and C3-8cycloalkyl;
• R4, R5, R8, and R9 are each independently selected from the group consisting of hydrogen, cyano, C1-4alkyl, C1-4alkoxy, amino, hydroxy, C3-8cycloalkyl, halo, and C1-4alkylamino;
• R6 is selected from the group consisting of amino, C1-4aminoalkyl, and C1-4alkylamino;
• R7 is selected from the group consisting of hydrogen, amido, cyano, halo, and hydroxy, or is selected from the group consisting of C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, and 5- or 6-membered heteroaryl, any of which is optionally substituted with one to five groups independently selected from the group consisting of amino, halo, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl, C1-4haloalkoxy, C1-4alkylamino, and C1-4aminoalkyl;
• or R6 and R7 together with the carbon atom to which they are both attached form a 3- to 7-membered saturated or unsaturated ring, having 0 to 3 heteroatoms or groups as ring vertices independently selected from N, C(O), O, and S(O)m;
• subscript m is 0, 1, or 2;
• said saturated or unsaturated ring formed by R6 and R7 is unsubstituted or substituted with 1 to 3 groups independently selected from the group consisting of amino, halo, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl, C1-4haloalkoxy, C1-4alkylamino and C1-4aminoalkyl;
• any two groups of R2, R3, R4, R5, R7, R8, R9, R10 and R11 can form a 5 to 6 membered ring, having 0 to 2 heteroatoms as ring verticess elected from N, O and S;
• any two groups of R2, R4, R6, R8 and R10 can form a direct bond, or a 1 or 2 atom carbon bridge;
• R13 is selected from the group consisting of hydrogen, halo, cyano, C1-6alkyl, C1-6haloalkyl, C1-6hydroxyalkyl, C1-6 dihydroxyalkyl, —NH—NHR19, —NHR19, —OR19, —NHC(O)R19, —NHC(O)NHR19, —NHS(O)2NHR19, —NHS(O)2R19, —C(O)OR19, —C(O)NR19R20, —C(O)NH(CH2)qOH, —C(O)NH(CH2)qR21, —C(O)R21, —NH2, —OH, —S(O)2NR19R20, C3-8cycloalkyl, aryl, heterocyclyl having 1-5 heteroatoms as ring vertices selected from N, O, S and P, heteroaryl having 1-5 heteroatoms as ring vertices selected from N, O, S and P;
• wherein the subscript q is an integer of from 0 to 6;
• and wherein aryl, heteroaryl, heterocyclyl and cycloalkyl are substituted with 0 to 3 groups independently selected from the group consisting of C1-4alkyl, —OH, —NH2, —OR21, halo, cyano, and oxo;
• R14, R15 and R16 are each independently selected from the group consisting of hydrogen, C1-4alkyl, C3-8cycloalkyl, C6-10aryl and 5-10 membered heteroaryl, each of which is optionally substituted by one or more groups independently selected from the group consisting of amido, amino, halo, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl, C1-4haloalkoxy, C1-4alkylamino and C1-4aminoalkyl;
• R17 and R18 are each independently selected from the group consisting of hydrogen, C1-4alkyl, and CF3;
• R19 and R20 are each independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6haloalkyl, C1-6hydroxyalkyl, C2-6alkenyl, C2-6alkynyl and C3-6cycloalkyl;
• and
• each R21 is independently selected from the group consisting of hydrogen, —OH, C1-6 alkyl, C1-6haloalkyl, C1-6hydroxyalkyl, C2-6alkenyl, C2-6alkynyl and C3-6cycloalkyl.