Aniline-substituted 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3-one derivative and use thereof

A compound of formula (II), or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof:

• wherein, Y is selected from the group consisting of a bond, NRa1, S, SO, SO2 and O;
• wherein Ra1 is selected from the group consisting of hydrogen, hydroxy and C1-8 alkyl;
• B is selected from the group consisting of C6-10 aryl, a 4- to 7-membered saturated or unsaturated monoheterocyclic ring, a 5- to 6-membered monocyclic heteroaryl ring, and an 8- to 10-membered bicyclic heteroaryl ring;
• Q is N or CRb1, wherein Rb1 is selected from the group consisting of hydrogen, halogen, cyano, C1-8 alkyl, halogenated C1-8 alkyl, C1-8 alkoxy, C3-8 cycloalkyl and C3-8 cycloalkoxy;
• three of Z1, Z2, Z3 and Z4 are CH, and one of Z1, Z2, Z3 and Z4 is N;
• or Z1, Z2, Z3 and Z4 are CH;
• R5 and R6 are each independently selected from the group consisting of hydrogen, halogen, C1-8 alkyl, halogenated C1-8 alkyl, C1-8 alkoxy, C3-8 cycloalkyl and C3-8 cycloalkoxy;
• R7 and R9 are each independently selected from the group consisting of hydrogen, C1-8 alkyl, halogenated C1-8 alkyl, and C3-8 cycloalkyl;
• R8 is selected from the group consisting of hydrogen, halogen, cyano, C1-8 alkyl, C1-8 alkoxy, halogenated C1-8 alkyl, C3-8 cycloalkyl and NRa0Rb0, wherein Ra0 and Rb0 are each independently selected from the group consisting of hydrogen, acetyl, C1-8 alkyl, C1-8 alkoxy-substituted C1-8 alkyl;
• j is 0, 1, 2, 3 or 4;
• and
• the alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, saturated or unsaturated monoheterocyclic ring, monocyclic heteroaryl ring, bicyclic heteroaryl ring are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxymethyl, hydroxyethyl, hydroxy, carboxyl, —O(CH2)pOC1-8 alkyl, —O(CH2)pOH, —(CH2)pOC1-8 alkyl, 4- to 6-membered saturated monoheterocyclic ring, C1-8 alkyl, C3-8 cycloalkyl, halogenated C1-8 alkyl, halogenated C3-8 cycloalkyl, hydroxy-substituted C1-8 alkyl, NRa0Rb0, —C(O)OC1-6 alkyl, acetyl, C1-8 alkoxy, C1-8 alkoxy-substituted C1-8 alkyl, halogenated C1-8 alkoxy, —SO2C1-8 alkyl, C6-10 aryl, 5- to 6-membered monocyclic heteroaryl and —Y-L, wherein Y is (CH2)q or C(O), L is a 4- to 6-membered saturated monoheterocyclic ring or a 5- to 6-membered monocyclic heteroaryl ring, q is 1, 2 or 3, and Ra0 and Rb0 are each independently selected from the group consisting of hydrogen, acetyl, C1-8 alkyl, and C1-8 alkoxy-substituted C1-8 alkyl.