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US 2020/0048235 A1Published application
Spiro compound and use thereof
AssigneeMedshine Discovery Inc.
InventorsPeng ZHANG, Lingyun WU, Jun YIN, Jian LI, Shuhui CHEN
Life of this patent
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Abstract
The present disclosure relates to a series of tricyclic compounds and the use thereof as receptor agonists of sphingosine-1-phosphate subtype 1 (S1P1), and in particular relates to compounds as shown in formula (I) or pharmaceutically acceptable salts thereof.
Claims22
A compound represented by formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof,
- wherein
- each R1 is independently selected from the group consisting of H, F, Cl, Br, I, OH, NH2, and CN, or is independently selected from the group consisting of C1-6 alkyl and C1-6 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 R;
- R2 is H, or is selected from the group consisting of C1-6 alkyl, C1-6 heteroalkyl and C3-6 cycloalkyl, each of which is optionally substituted by 1, 2 or 3 R;
- T is selected from the group consisting of N and CH;
- moiety
- is selected from the group consisting of
- moiety
- is selected from the group consisting of
- ring B is selected from the group consisting of phenyl and 5- to 6-membered heteroaryl;
- m is 1 or 2;
- n is 0, 1, 2 or 3;
- R is selected from the group consisting of F, Cl, Br, I, OH, NH2, CN, and COOH, or is selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, N,N-di(C1-6 alkyl)amino, and C3-6 cycloalkyl;
- the heteroatom or the heteroatom group of the C1-6 heteroalkyl and the 5- to 6-membered heteroaryl is each independently selected from the group consisting of N, O, S, NH, —NHC(═O)—, —S(═O)— and —S(═O)2—;
- and
- the number of the heteroatom or the heteroatom group is 1, 2, 3 or 4.
12 more elements
A compound represented by the following formula, an optical isomer thereof or a pharmaceutically acceptable salt thereof, which is selected from the group consisting of
Dependencies are inferred from the claim text.