Apoptosis signal-regulating kinase 1 (ask 1) inhibitor compounds

A compound of Formula (I), or a pharmaceutically acceptable salt, or solvate thereof:

• wherein,
• ring A is a phenyl, 6-membered heteroaryl, or a 5-membered heteroaryl;
• each Ra is independently H, D, halogen, —CN, —OR5, —SRS, —S(═O)R4, —S(═O)2R4, —S(═O)2N(R5)2, —NR5S(═O)2R4, —C(═O)R4, —OC(═O)R4, —CO2R5, —OCO2R4, —N(R5)2, —OC(═O)N(R5)2, —C(═O)N(R5)2, —NR5C(═O)R4, —NR5C(═O)OR4, —NR5C(═O)N(R5)2, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C6cycloalkyl;
• m is 0, 1, 2, or 3;
• R1 is H, D, halogen, —CN, —OR5, —SR5, —S(═O)R4, —S(═O)2R4, —N(R5)2, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, or substituted or unsubstituted -C1-C4alkylene-N(R5)2;
• L1 is linker that is —X2—, L2, -L2—X2—, —X2-L3—, or -L2—X2-L3—;
• X2 is —O—, —S—, —S(═O)—, —S(═O)2—, —S(═O)2NR6—, —C(═O)—, —C(═O)O—, —C(═O)NR6—, —OC(═O)NR6—, —NR6C(═O)O—, —NR6C(═O)NR6—, —OC(═O)—, —NR6C(═O)—, —NR6S(═O)2—, or —NR6—;
• R6 is H, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
• L2 is substituted or unsubstituted C1-C4alkylene, substituted or unsubstituted C2-C4alkenylene or substituted or unsubstituted C2-C4alkynylene;
• L3 is C1-C4alkylene;
• X1 is CR2 or N;
• X2 is CR2 or N;
• each R2 is independently H, D, halogen, —CN, —OR5, —SR5, —S(═O)R4, —S(═O)2R4, —N(R5)2, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C6cycloalkyl;
• R3 is H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, or substituted or unsubstituted C1-C6deuteroalkyl;
• ring B is a 6-membered heteroaryl, phenyl, or a 5-membered heteroaryl;
• each Rb is independently H, D, halogen, —CN, —OR5, —SRS, —S(═O)R4, —S(═O)2R4, —S(═O)2N(R5)2, —NR5S(═O)2R4, —C(═O)R4, —OC(═O)R4, —CO2R5, —OCO2R4, —N(R5)2, —OC(═O)N(R5)2, —NR5C(═O)R4, —NR2C(═O)OR4, —C(═O)N(R5)2, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C6cycloalkyl;
• n is 0, 1, 2, 3, or 4;
• ring C is a 5-membered heteroaryl;
• each Rc is independently H, D, halogen, —CN, —OR5, —SR5, —S(═O)R4, —S(═O)2R4, —S(═O)2N(R5)2, —NR5S(═O)2R4, —C(═O)R4, —OC(═O)R4, —CO2R5, —OCO2R4, —N(R5)2, —OC(═O)N(R5)2, —NR5C(═O)R4, —NR5C(═O)OR4, —C(═O)N(R5)2, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, or substituted or unsubstituted C3-C6cycloalkyl;
• p is 0, 1, 2, or 3;
• each R4 is independently selected from C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl and substituted or unsubstituted heteroaryl;
• each R5 is independently selected from H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl and substituted or unsubstituted heteroaryl;
• or two R5 on the same N atom are taken together with the N atom to which they are attached to a substituted or unsubstituted N-containing heterocycle.