Indenyl compounds, pharmaceutical compositions, and medical uses thereof

A compound, (Z)- or (E)-isomer thereof, of formula IIa:

• wherein:
• R1, R2, R3 and R4 are independently selected from hydrogen, halogen, alkyl, cycloalkyl, haloalkyl, and alkoxy;
• R7 and R8 are independently selected from hydrogen and alkyl;
• R13 and R15 are independently selected from hydrogen, halogen, alkyl, haloalkyl and alkoxy;
• R14 is selected from hydroxyl, carboxyl, cyano, cyanoalkyl, nitro, oxo, amino, alkylamino, aminoalkyl, alkylaminoalkyl, hydroxyalkyl, aldehydo, mercapto and alkylmercapto.
• R′ is selected from the group consisting of heterocyclyl and heterocyclylalkyl, wherein the heterocyclyl of the heterocyclyl and heterocyclylalkyl is selected from the group consisting of azepanyl, oxazepanyl, thiazepanyl, azepinyl, oxepinyl, thiepanyl, homopiperazinyl, diazepinyl, thiazepinyl, oxanyl, thianyl, pyranyl, thiopyranyl, thiomorpholinyl, dioxanyl, dithianyl, diazinyl, oxazinyl, thiazinyl, dioxinyl, dithiinyl, trioxanyl, trithianyl, triazinyl, tetrazinyl, tetrahydrofuranyl, tetrahydrothiophenyl, thiophenyl, imidazolidinyl, pyrazolidinyl, oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, dioxolanyl, dithiolanyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, furazanyl, oxadiazolyl, thiadiazolyl, dithiazolyl and tetrazolyl, wherein the heterocyclyl of the heterocyclyl and heterocyclylalkyl of the R′ is optionally substituted with one or more of halo, alkyl, haloalkyl, hydroxyl, alkoxy, amino, alkylamino, dialkylamino, mercapto, alkylmercapto, carboxamido, aldehydo, cyano, oxo, alkylcarbonyloxy, and sulfonamido;
• or
• a pharmaceutically acceptable salt thereof.