Sodium ion channel inhibitors and pharmaceutically acceptable salts and polymorphs thereof and uses thereof
AssigneesShanghai Haiyan Pharmaceutical Technology Co., Ltd., Yangtze River Pharmaceutical Group Co., Ltd.
InventorsZheng WANG, Taotao JIANG, Jibiao WANG
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Abstract
The present disclosure discloses sodium ion channel inhibitors, pharmaceutically acceptable salts and polymorphs thereof, and uses thereof. Specifically, the present disclosure discloses a polymorph of a compound of formula (X) and a preparation method thereof. The preparation method of the present disclosure is simple in operation and suitable for industrialization. The polymorph prepared by the preparation method has advantages of good stability, low hygroscopicity and high water solubility.
Claims9
A pharmaceutically acceptable salt of a compound of formula (X), or a polymorph thereof
A process for preparing a pharmaceutically acceptable salt of a compound of formula X or a polymorph thereof, wherein the process comprises the following steps:
- (1) reacting a compound of formula X-4 with a compound of formula X-a under an alkaline condition to form the compound of formula X;
- (2) optionally, reacting the compound of formula X with an acid or a base to form a pharmaceutically acceptable salt of the compound of formula X;
- (3) optionally, performing crystallization processing on the compound of formula X formed in step (1), or the pharmaceutically acceptable salt of the compound of formula X formed in step (2), to obtain a polymorph of the compound of formula X or a polymorph of the pharmaceutically acceptable salt of the compound of formula X.
Dependencies are inferred from the claim text.