TREATMENT OF DISEASES OR DISORDERS CAUSED BY INDUCED NFkB TRANSCRIPTIONAL ACTIVITY
AssigneeSenex Biotechnology, Inc.
InventorsDonald C. PORTER, Igor B. RONINSON
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Abstract
The invention provides a method for treating a disease or disorder in a mammal which is caused by induced NFkB transcriptional activity in cells of the mammal, the method comprising administering to the mammal a compound that specifically inhibits one or more of CDK8 and CDK19.
Claims21
-19. (canceled)
A method for treating an inflammatory disease or disorder in a mammal which is caused by induced NF-κB transcriptional activity in cells of the mammal, the method comprising administering to the mammal a compound that specifically inhibits one or more of CDK8 and CDK19, wherein the induced NF-κB transcriptional activity is inhibited without inhibiting basal NF-κB transcriptional activity.
A method for inhibiting induced NF-κB transcriptional activity in a mammalian cell, wherein the NF-κB transcriptional activity is not induced via the CKI pathway, the method comprising contacting the cell with a compound having the structure
- wherein
- R1 is aralkyl, wherein aryl is naphthyl;
- R2 is selects from lower alkyl and hydrogen;
- A is selected from lower alkyl and hydrogen;
- and
- B is selected from halogen, cyano, trifluoromethyl, NHAc, NO2, and O-lower alkyl.
Dependencies are inferred from the claim text.