Method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine

A method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine, comprising:

• Step 1:
• adding p-bromophenylacetic acid and a solid acid catalyst to a reactor, then adding methanol, heating with stirring, and refluxing to react for 5-6 hours under reflux;
• and cooling the reaction solution to 30° C. or below, filtering to recover the solid acid catalyst, distilling the resulting filtrate under reduced pressure to remove methanol, adding a hydrophobic solvent to dissolve the residue by stirring, washing the hydrophobic solvent with water, and concentrating under reduced pressure to obtain Intermediate 1 having a chemical structure (I) below;
• Step 2:
• adding sodium methoxide and methanol to Intermediate 1 obtained in Step 1, mechanically stirring, then adding dimethyl carbonate, replacing the air in the reactor with nitrogen, heating to 70-80° C., and reacting for 4-8 hours, to obtain a mixture containing Intermediate 2 having a chemical structure (II) below;
• Step 3:
• adding formamidine hydrochloride to the mixture containing Intermediate 2 obtained in Step 2, heating to 20-30° C. with stirring, and reacting for 15-17 hours, followed by post-treatment, to obtain Intermediate 3 having a chemical structure (III) below;
• and
• Step 4:
• chlorinating Intermediate 3 obtained in Step 3 to obtain the product 5-(4-bromophenyl)-4,6-dichloropyrimidine.