Modulators of cell adhesion, methods and compositions therefor
AssigneeZonula, Inc.
InventorOrest William Blaschuk
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Abstract
Compounds with activity as modulators of cell adhesion are disclosed. The compounds are derivatives of piperidin-4-amine. In some embodiments, a compound can be linked to a targeting agent, a pharmaceutically active substance and/or a support material. Methods for enhancing or inhibiting classical cadherin-mediated functions are also disclosed. The compounds can be used for the treatment or prevention of a variety of diseases including cancer. Compositions and devices, including skin patches comprising a compound are also disclosed. In addition, methods of synthesis of the compounds are provided.
Claims16
A method of treating a fibrotic disease in a subject in need thereof, the method comprising administering to a subject in need thereof a therapeutically effective amount (S)-1-(3,4-dichlorophenoxy)-3-(4-(((S)-2-hydroxy-3-(4-methoxyphenoxy)propyl)amino)piperidin-1-yl)propan-2-ol
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.