Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators

A compound of formula II:

• wherein:
• (1) A is
• B is B1 and R5 is R5a;
• or
• (2) A is
• B is B2 and R5 is R5b;
• or
• (3) A is
• B is B3 and R5 is R5a;
• or
• (4) A is
• B is B4 and R5 is R5a;
• or
• (5) A is
• B is B1 and R5 is R5a;
• or
• (6) A is
• B is B5 and R5 is R5a;
• or
• (7) A is
• B is B3 and R5 is R5a;
• B is B1, B2, B3, B4, or B5;
• B1 is a 5-membered heteroaryl comprising 2 or 3 nitrogen atoms in the ring or a 6-membered heteroaryl, wherein any 5-membered heteroaryl or 6-membered heteroaryl of B1 is optionally substituted with one or more groups independently selected from halogen, (C1-C6)alkyl, —O(C1-C6)alkyl and (C3-C7)cycloalkyl;
• B2 is a pyridinyl, wherein any pyridinyl of B2 is optionally substituted with one or more groups independently selected from halogen, (C1-C6)alkyl, —O(C1-C6)alkyl, —O(C1-C6)alkyl-O(C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl, —CN, and 6-membered heteroaryl, wherein any 6-membered heteroaryl is optionally substituted with one or more (C1-C6)alkyl or (C1-C6)haloalkyl;
• B3 is a 5-membered heteroaryl comprising 2 or 3 nitrogen atoms in the ring or a 6-membered heteroaryl comprising 2 nitrogen atoms in the ring, wherein any 5-membered heteroaryl or 6-membered heteroaryl of B3 is optionally substituted with one or more groups independently selected from halogen, (C1-C6)alkyl, —O(C1-C6)alkyl, (C3-C7)cycloalkyl, —CN, and NR62, and wherein when B3 is pyrimidinyl which is attached to the remainder of Formula II at the 4 and 6 positions of the pyrimidinyl, then R5a is not pyrrolidinyl or substituted pyrrolidinyl;
• B4 is a 5-membered heteroaryl, 6-membered heteroaryl, or phenyl, wherein any 5-membered heteroaryl, 6-membered heteroaryl, or phenyl of B4 is optionally substituted with one or more groups independently selected from halogen, —CN, (C1-C6)alkyl, —O(C1-C6)alkyl and (C3-C7)cycloalkyl;
• B5 is a phenyl optionally substituted with one or more groups independently selected from —CN, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, —O(C1-C6)alkyl, and —O(C1-C6)haloalkyl;
• R1 is a phenyl, 5-membered heteroaryl or 6-membered heteroaryl, wherein any phenyl, 5-membered heteroaryl or 6-membered heteroaryl of R1 is optionally substituted with one or more groups independently selected from halogen, —CN, (C1-C6)alkyl and (C1-C6)haloalkyl;
• R2 is halogen, (C1-C6)alkyl or CN, wherein any (C1-C6)alkyl of R2 is optionally substituted with one or more groups independently selected from halogen, —OH and —O(C1-C6)alkyl;
• each R3a is independently selected from H, halogen and (C1-C6)alkyl;
• one R3b group is halogen, —CN, or (C1-C6)alkyl and the remaining R3b groups are independently selected from H, (C1-C6)alkyl and (C1-C6)haloalkyl;
• one R3b′ group is halogen, (C1-C6)alkyl, —CN, or (C1-C6)haloalkyl and the remaining R3b′ groups are independently selected from H, (C1-C6)alkyl and (C1-C6)haloalkyl;
• two R3c groups attached to different non-adjacent carbon atoms or adjacent carbon atoms are combined to form a (C1-C4)alkyl linker or a (C1-C2)alkyl-O—(C1-C2)alkyl linker, wherein the (C1-C4)alkyl linker or (C1-C2)alkyl-O—(C1-C2)alkyl linker is optionally substituted with one or more groups independently selected from halogen and (C1-C6)alkyl, and the remaining R3c groups are independently selected from H, halogen and (C1-C6)alkyl;
• each R3d group is independently selected from H, halogen, (C1-C6)alkyl, and —CN, wherein any (C1-C6)alkyl of R3d is optionally substituted with one or more groups independently selected from halogen, —OH and —O(C1-C6)alkyl;
• one R3e group is halogen, —CN or (C1-C6)alkyl and the remaining R3e groups are independently selected from H, (C1-C6)alkyl and (C1-C6)haloalkyl;
• two R3f groups attached to the same carbon atom are combined to form a (C2-C4)alkyl linker, wherein the (C2-C4)alkyl linker is optionally substituted with one or more groups independently selected from halogen and (C1-C6)alkyl, and the remaining R3f groups are independently selected from H, halogen and (C1-C6)alkyl;
• R4 is H, (C1-C6)alkyl or (C1-C6)haloalkyl;
• R5 is R5a or R5b;
• R5a is a phenyl, 5-membered heteroaryl, 6-membered heteroaryl, 4, 5, 6 or 7-membered heterocycle or (C3-C8)cycloalkyl, wherein any phenyl, 5-membered heteroaryl, 6-membered heteroaryl, 4, 5, 6 or 7-membered heterocycle or (C3-C8)cycloalkyl of R5a is optionally substituted with one or more groups independently selected from halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, —CN, (C3-C7)cycloalkyl, —O(C1-C6)alkyl, —O(C1-C6)alkyl-O(C1-C6)alkyl, —O(C1-C6)haloalkyl, —S(C1-C6)alkyl, —S(C1-C6)haloalkyl, oxo and —O—(C1-C2)alkyl-O— optionally substituted with one or more halogen, which —O—(C1-C2)alkyl-O— group is bonded to two adjacent carbon atoms of any phenyl, 5-membered heteroaryl, 6-membered heteroaryl, 4, 5, 6 or 7-membered heterocycle or (C3-C8)cycloalkyl of R5a;
• R5b is a phenyl, 5-membered heteroaryl, 6-membered heteroaryl or 4, 5, 6, 7 or 8-membered heterocycle, wherein any phenyl, 5-membered heteroaryl, 6-membered heteroaryl or 4, 6, 7 or 8-membered heterocycle of R5b is optionally substituted with one or more groups independently selected from halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, —CN, (C3-C7)cycloalkyl optionally substituted with one or more halogen, —O(C1-C6)alkyl, —O(C1-C6)haloalkyl, —OH, —S(C1-C6)alkyl, —S(C1-C6)haloalkyl, and NR62, and wherein any 5-membered heterocycle of R5b is substituted with one or more groups independently selected from halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, —CN, (C3-C7)cycloalkyl, —O(C1-C6)alkyl, —O(C1-C6)haloalkyl, —S(C1-C6)alkyl and —S(C1-C6)haloalkyl;
• and
• each R6 is independently H or (C1-C6)alkyl;
• or a salt thereof.